I'm guessing you mean they also are on different teams? In that case, if you have two family members that collect both teams (say, Red Sox and Blue Jays) and both players on the card are from each team (perhaps Bautista and Betts), I see three options:
1) Keep it and send it to neither
2) Get another one and send both a copy of the card
3) Just pick one and send it to them
If you're referring to a situation where it's two players for the same team, obviously go ahead and send it anyway.
But I'm guessing it's two different players on two different teams, hence the question.
Jason
I'll never quit collecting entirely, but I am downsizing. Check out my COMC store and help me thin out what I don't want so I can buy cards that I do want. See something you like? Send me a message on here, and we can knock the price down quite a bit. I'll even take a bit of a loss if it means getting you a card you really want.